Synthesis, Characterization and Biological Evaluation of Some Novel Chalcone Derivatives Containing Imidazo[1,2-a]Pyridine Moiety

Abstract

Chalcone was prepared by the condensation of arylmethyl ketone and arylaldehyde in the presence of alcoholic alkali. Present study describes the synthesis of a series of (2z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a] pyridine-3-yl]-1-substituted arylprop-2-en-1-one compounds (h) 1-9. The compounds were characterized by modern analytical techniques such as CHN analyses, IR, 1H NMR spectra and further supported by mass spectroscopy. All the title compounds were screened for their in vitro antibacterial and antifungal activity against B.coccus, S.aureus, Pseudomona, E.coli, A.niger, Ampicillin, Amoxicillin, Ciprofloxacin, Norfloxacin, Greseofulvin. Their minimum inhibitory concentrations (MIC) were determined. The results of antibacterial activity showed that compounds h 4, h 9 and antifungal activity compounds h 1, h 9 using standard drug.